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Zyprexa tablets contain the active ingredient olanzapine, which is a type of medicine known as an atypical antipsychotic (a "mood stabilizer"), used to help manage symptoms of schizophrenia, the manic phase of manic-depression, and other psychotic disorders.
Zyprexa has obtained FDA approval as a mood stabilizer.
It's a very fast, often extremely effective medication for the symptoms of bipolar disorder (it even may help antidepressants work in people who don't clearly have bipolar disorder.)
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Zyprexa (Olanzapine) Information
The active ingredient of Zyprexa, known as olanzapine, is believed to work by opposing the action of serotonin and dopamine transmission, two of the brain's important chemical messengers. Serotonin is involved in the regulation of sleep, appetite, sexual desire, and mood, while dopamine helps control movement, cognition, and motivation.
Zyprexa differs from older antipscyhotic drugs because it allegedly causes fewer cases of severe side effects such as extrapyramidal symptoms and neuroleptic malignant syndrome.
This medication can be unbelievably effective, with remarkably few side effects.
How does Olanzapine work?
Olanzapine works in the brain, where it affects various neurotransmitters, in particular serotonin (5HT) and dopamine. Neurotransmitters are chemicals that are stored in nerve cells and are involved in transmitting messages between the nerve cells.
Olanzapine works by blocking the receptors in the brain that dopamine acts on. This prevents the excessive activity of dopamine and helps to control schizophrenia.
Olanzapine is effective in relieving both positive and negative symptoms of schizophrenia, whereas the conventional antipsychotics are usually less effective against the negative symptoms.
What should I know about Zyprexa dosing?
The recommended starting Zyprexa dose for schizophrenia is Zyprexa 5 mg to 10 mg once daily. If you start at less than Zyprexa 10 mg daily, your healthcare provider may increase the dose of Zyprexa to 10 mg within the first few days.
The recommended starting Zyprexa dose for treating manic or mixed episodes in bipolar disorder is Zyprexa 10 mg to 15 mg once daily. If bipolar disorder symptoms continue after several weeks.
Once your bipolar symptoms are improved, your healthcare provider may choose to stop the Zyprexa or keep you on Zyprexa at doses of Zyprexa 5 mg to 20 mg per day. The maximum dose for Zyprexa is 20 mg per day.
Olanzapine side effects
Olanzapine can occasionally cause your blood pressure to drop when you move from a lying down or sitting position to sitting or standing, especially when you first start taking the medicine.
This medicine can cause some people to put on weight.
Consult your doctor immediately if you experience abnormal movements, particularly of the face, lips, jaw and tongue, while taking this medicine. These symptoms may be indicative of a rare side effect known as tardive dyskinesia, and your doctor may ask you to stop taking this medicine, or decrease your dose.
The components of tobacco smoke can cause this medicine to be removed from the body faster than normal.
Allergic reaction
An allergic reaction may cause an itchy rash or shortness of breath, and may occur as soon as you start treatment, or after you have taken the medicine for some time. Consult your doctor if you experience these symptoms.
